Comparative genomics has proven a fruitful approach to acquire many functional and evolutionary insights into core cellular processes. Here it is argued that in order to perform accurate and interesting comparative genomics, one first and foremost has to be able to recognize, postulate, and revise different evolutionary scenarios. After all, these studies lack a simple protocol, due to different proteins having different evolutionary dynamics and demanding different approaches. The authors here discuss this challenge from a practical (what are the observations?) (...) and conceptual (how do these indicate a specific evolutionary scenario?) viewpoint, with the aim to guide investigators who want to analyze the evolution of their protein(s) of interest. By sharing how the authors draft, test, and update such a scenario and how it directs their investigations, the authors hope to illuminate how to execute molecular evolution studies and how to interpret them. Also see the video abstract here https://youtu.be/VCt3l2pbdbQ. (shrink)

There are methodological problems with the new techniques reviewed by Posner & Raichle. Some brain mechanisms are not detected by the temporal and spatial resolution. Questions are also raised by the stimulation paradigms.

This volume marks a unique collaboration by internationally distinguished scholars in the history, rhetoric, philosophy, and sociology of science. Converging on the central issues of rhetoric of science, the essays focus on figures such as Galileo, Harvey, Darwin, von Neumann; and on issues such as the debate over cold fusion or the continental drift controversy. Their vitality attests to the burgeoning interest in the rhetoric of science.

This article argues for two theses. The first is that many of the sociological factors endemic in the philosophical community function as barriers to the recruitment of members of minority groups in the profession and to their functioning as public intellectuals. The division into familial groups, the fights for security and success, and the weakness of the federal organization of the American Philosophical Association all contribute to these barriers. The second is that sociology has a place in philosophy, even though (...) it should not be confused with it. This means that philosophers need to consider social phenomena. (shrink)

The primary function of a book review is to articulate and present an understanding of the book's thesis and argument, and to make a judgment as to its value, so that readers will themselves understand and be guided by the understanding and judgment of the reviewer. Reviews are supposed to be interpretations created for the sake of a potential audience for a book. Unfortunately, most reviews fail to fulfill this function insofar as they merely paraphrase the text they are supposed (...) to interpret, fail to provide an understanding of it, or are so critical that they miss the significance of the book. In short, they fail to provide the kind of interpretation that constitutes their proper hermeneutic task. Glover's .. (shrink)

This chapter contains section titled: Philosophical Canons The Place of Latino Philosophy in the Canon Reasons for the Exclusion of Latino Philosophy from the Canon Philosophical Canons and Philosophical Traditions Philosophical Canons in the United States Latino Philosophy and the Western Philosophical Tradition Incorporating Latino Philosophy into the Philosophical Canon Latin America, Globalization, and the Future of Latino Philosophy Latino Philosophy and the Canon.

Despite predictions that Hispanics will soon outnumber all other minority groups combined in the United States, philosophy has remained indifferent to the growing Hispanic population. This paper offers several hypotheses why this is the case, arguing that Hispanics and Hispanic thought are perceived as unphilosophical (or only narrowly philosophical) and are thus perceived as ill-suited for academia and academic discussions in the United States. The author concludes by proposing strategies for overcoming this marginalization of Hispanics and Hispanic philosophy.

This chapter contains section titled: Two Dilemmas Four Basic Questions about Identity The Familial—Historical View of Latino Identities Ethnicity and Nationality Latino Identities.

Citing of previous publications is an important factor in knowledge development. Because of the great amount of publications available, only a selection of studies gets cited, for varying reasons. If the selection of citations is associated with study outcome this is called citation bias. We will study determinants of citation in a broader sense, including e.g. study design, journal impact factor or the funding source of the publication. As a case study we assess which factors drive citation in the human (...) literature on phthalates, specifically the metabolite mono phthalate. A systematic literature search identified all relevant publications on human health effect of MEHP. Data on potential determinants of citation were extracted in duplo. Specialized software was used to create a citation network, including all potential citation pathways. Random effect logistic regression was used to assess whether these determinants influence the likelihood of citation. 112 Publications on MEHP were identified, with 5684 potential citation pathways of which 551 were actual citations. Reporting of a harmful point estimate, journal impact factor, authority of the author, a male corresponding author, research performed in North America and self-citation were positively associated with the likelihood of being cited. In the literature on MEHP, citation is mostly driven by a number of factors that are not related to study outcome. Although the identified determinants do not necessarily give strong indications of bias, it shows selective use of published literature for a variety of reasons. (shrink)

This chapter contains section titled: Our Philosophy The Problem of Latino Philosophy Historiographical Characterizations of Philosophy Latino Conceptions of Latino Philosophy Latino Philosophy as Ethnic Philosophy Latino Philosophy and “Scientific” Philosophy Universalism, Culturalism, and Critical Philosophy Revisited American Philosophy Latino and American Philosophy.

The current Medicare prospective payment system has many positive incentives for hospitals to control costs. Hospitals are increasing outpatient surgery, decreasing admissions, decreasing length of stay, and decreasing use of ancillary services. These are just the effects that Congress and the Health Care Financing Administration hoped for to save the Medicare trust fund. However, there has been evidence of some adverse outcomes including premature discharge, “dumping” sicker patients and patients without insurance, and adverse impact on hospitals with specialty centers. We (...) examine these issues and present a possible solution based on a new Computerized Severity Index. (shrink)